2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P5939
    Angiotensinogen (1-13) (human) 82048-97-3 98%
    Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.
    Angiotensinogen (1-13) (human)
  • HY-P5950
    ACTH (6-24) (human) 33512-65-1 98%
    ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (Kd:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34.
    ACTH (6-24) (human)
  • HY-P5951
    Adrenomedullin (1-12) (human) 161206-81-1 98%
    Adrenomedullin (1-12) (human) is adrenomedullin fragment. Adrenomedullin has no effect on arterial pressure in cats
    Adrenomedullin (1-12) (human)
  • HY-P5978
    Atriopeptin III (rat) 90817-13-3 98%
    Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure.
    Atriopeptin III (rat)
  • HY-P5991
    K-Casein (106-116),bovine 103951-35-5 98%
    K-Casein (106-116),bovine is a peptide that inhibits platelet aggregation and fibrinogen binding, plays an important role in atherosclerosis.
    K-Casein (106-116),bovine
  • HY-P6008
    Myoregulin 98%
    Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca2+-ATPase (SERCA) and impedinf Ca2+ uptake into the sarcoplasmic reticulum.
    Myoregulin
  • HY-Z0081
    2S,4R-Sacubitril 2307668-79-5 98%
    2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2S,4R-Sacubitril
  • HY-Z7082
    Perindopril L-arginine 612548-45-5 98%
    Perindopril L-arginine is an orally active and selective angiotensin-converting enzyme (ACE) inhibitor. Perindopril L-arginine reduces the production of angiotensin II by inhibiting ACE, thereby dilating blood vessels, lowering blood pressure, and also exerting activities such as vasculoprotection and antithrombosis. Perindopril L-arginine is promising for research of cardiovascular diseases.
    Perindopril L-arginine
  • HY-100141
    Ancarolol 75748-50-4 98%
    Ancarolol is a beta-adrenergic blocking agent.
    Ancarolol
  • HY-100151
    RGH-5526 69579-13-1 98%
    RGH-5526 (GYKI-11679) is a new antihypertensive agent.
    RGH-5526
  • HY-100160
    RP 54275 81364-78-5 98%
    RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic agent.
    RP 54275
  • HY-100171
    PRX933 hydrochloride 639029-42-8 98%
    PRX933 hydrochloride is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1.
    PRX933 hydrochloride
  • HY-100194
    FKK 78299-79-3 98%
    FKK is an indazole derivative and also a novel bronchodilator.
    FKK
  • HY-100239
    ICI 153110 87164-90-7 98%
    ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure.
    ICI 153110
  • HY-100245
    OM-189 55381-18-5 98%
    OM-189 is a selective synthetic thrombin inhibitor.
    OM-189
  • HY-100253
    TA-7552 104756-72-1 98%
    TA-7552 is a potent cholesterol-lowering agent.
    TA-7552
  • HY-100254
    TAK-024 186971-69-7 98%
    TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.
    TAK-024
  • HY-100258
    Y-9738 59399-41-6 98%
    Y-9738 is a hypolipidemic agent.
    Y-9738
  • HY-100295
    (4-Acetamidocyclohexyl) nitrate 137213-91-3 98%
    (4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.
    (4-Acetamidocyclohexyl) nitrate
  • HY-100299
    RPR107393 free base 197576-78-6 98%
    RPR107393 free base is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 free base inhibits rat liver microsomal squalene synthase with an IC50 value of 0.8 nM. RPR107393 free base reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 free base reduces plasma cholesterol in rats and marmosets. RPR107393 free base can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis[1][2].
    RPR107393 free base
Cat. No. Product Name / Synonyms Application Reactivity